Multi Object Texture (using Region) vs Single Object Texture

Question

So.. Recently i'm questioning which is better..
Which is faster between these two?

Example~
case 1:
i have 3 sprites. Desk, chair, and a plate. All sprites using a single texture and region enabled. (objects.png)

case 2:
same sprites but unlike before, all sprites using their own texture file. (desk.png, chair.png, plate.png)

Just curious.. currently i'm using the 1st case on my game, but i'm afraid if it actually affect the performance of the game on low-specs phone

Thank you before